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Protein subcellular localization

Due to the close correlation between the subcellular location of a protein and its biological function, the knowledge of subcellular location can help to characterize the protein functions.

Structural entropy and thermostability

We developed a technique to compute the structural entropy directly from protein sequences. We explored the possibility of using structural entropy to identify residues involved in thermal stabilization of various protein families.

Structural alignment

Identify functional structural motifs from structures of unknown function becomes increasingly important in recent years due to the progress of the structural genomics projects.

Molecular Simulation

Understanding the molecular origin of enzyme catalysis is one of the most fundamental problems in molecular biology.


Recent works have demonstrated that microRNAs (miRNAs) are involved in critical biological processes by suppressing the translation of coding genes.

Protein Post-translational Modification

Protein Post-Translational Modification (PTM) plays an essential role in cellular control mechanisms that adjust protein physical and chemical properties, folding, conformation, stability and activity, thus also altering protein function.

Protein-Protein (Protein-DNA) Interaction

System Biology: Protein-Protein (Protein-DNA) Interaction/Docking & Pathway

Protein Folding & Structural Bioinformatics

Protein Folding & Structural Bioinformatics

Machine Learning and Applications

Genetic algorithms, evolution strategies, and evolutionary programming