Identify functional structural motifs from structures of unknown function becomes increasingly important in recent years due to the progress of the structural genomics projects.
Though some structural patterns such as the Asp-His-Ser catalytic triad are easy to detect because of their conserved residues and the stringently constrained geometry, it is usually more challenging to detect a general structural motifs like, for example, Beta beta alpha-metal binding motif, which has a much more variable conformation and sequence. At present, the identification of these motifs usually replies on manual procedures based on different structure and sequence analysis tools. We have developed a structural alignment algorithm combining both structural and sequence information to identify the local structure motifs.
We coperate with...