Introduction to Computational Biology Laboratory

Research on * Structure prediction and classification * Prediction of protein subcellular localization * Disulfide proteins * Protein stability * Structural alignment * Molecular Simulation * Sequence coupling * Whatever is fun.

  • Projects - a list of Faculty-led research projects in Human genetics

Projects

  • Protein subcellular localization

    Due to the close correlation between the subcellular location of a protein and its biological function, the knowledge of subcellular location can help to characterize the protein functions. Therefore, a reliable, automated prediction tool for subcellular localization will be useful for the characterization of expressed protein sequences. We have developed a method CELLO based on Sopport Vector Machine to predict the subcellular.....

  • Structural entropy and thermostability

    We developed a technique to compute the structural entropy directly from protein sequences. We explored the possibility of using structural entropy to identify residues involved in thermal stabilization of various protein families......

  • Structural alignment

    Identify functional structural motifs from structures of unknown function becomes increasingly important in recent years due to the progress of the structural genomics projects. Though some structural patterns such as the Asp-His-Ser catalytic triad are easy to detect because of their conserved residues and the stringently constrained geometry, it is usually more challenging to detect a general structural motifs like,......

  • Molecular Simulation

    Understanding the molecular origin of enzyme catalysis is one of the most fundamental problems in molecular biology. The effects of enzymes on the reacting substrates involve varied and complicated energy contributions which depend on the structure of the enzyme-substrate complex. Thus to have a quantitative structure-function relationship is not a trivial matter. In principle,......